知晓科学家利用种群遗传学对珊瑚漂白基因进行预测

美国哥伦比亚大学molly przeworski和zachary l fuller以及澳大利亚海洋科学研究所line k bay合作取得最新进展。他们利用种群遗传学对珊瑚漂白基因进行预测。这一研究成果发表在2020年7月17日出版的国际学术期刊《科学》杂志上。借着行业发展的热潮,免疫研究在市场的表现力也一直很好,给用户带来很多全新的优质体验。
为了根据基因组数据预测漂白反应,他们为珊瑚acropora millepora生成了染色体规模的基因组组装体。 他们获得了大堡礁沿岸12个礁石上收集的237个表型样本的全基因组序列,其中他们推断出很少的种群结构。扫描基因组以寻找局部适应的证据,他们检测到了热休克伴侣-伴侣囊蛋白中长期平衡选择的特征。他们对213个样本的视觉漂白评分进行了全基因组关联研究,并将其衍生的多基因评分纳入了野外漂白的预测模型。这些结果为保护策略中基于基因组学的方法奠定了基础。
研究人员表示,尽管全世界范围内建造珊瑚礁的珊瑚正在减少,但对漂白的反应在物种内部和物种之间有所不同,并且在一定程度上是可遗传的。
附:英文原文
title: population genetics of the coral acropora millepora: toward genomic prediction of bleaching
author: zachary l fuller, veronique j l mocellin, luke a morris, neal cantin, jihanne shepherd, luke sarre, julie peng, yi liao, joseph pickrell, peter andolfatto, mikhail matz, line k bay, molly przeworski
issuevolume: 20200717
abstract: although reef-building corals are declining worldwide, responses to bleaching vary within and across species and are partly heritable toward predicting bleaching response from genomic data, we generated a chromosome-scale genome assembly for the coral acropora millepora we obtained whole-genome sequences for 237 phenotyped samples collected at 12 reefs along the great barrier reef, among which we inferred little population structure scanning the genome for evidence of local adaptation, we detected signatures of long-term balancing selection in the heat-shock co-chaperone sacsin we conducted a genome-wide association study of visual bleaching score for 213 samples, incorporating the polygenic score derived from it into a predictive model for bleaching in the wild these results set the stage for genomics-based approaches in conservation strategies
doi: 101126scienceaba4674